New contraceptive method to move forward in development!

Contraception in development is probably my biggest pet project; I’ve given a couple presentations on the one-time reversible injection method, called RISUG.  After injecting this compound into the vas deferens, the sperm will be unable to penetrate the jelly coat of the egg, and thus, pregnancy is prevented.  The most amazing aspect of this birth control method is that it is effective for at least 10 years, and is completely reversible.  RISUG (which stands for reversible inhibition of sperm under guidance) is cheap and low maintenance, with few to no side effects observed in most subjects.  Plus, the procedure takes about five minutes.

The good news is, thanks to all of the people that filled out the petition and survey on , RISUG will be resuming testing in the United States within the next five years! Since 2001 or so, a company in India held the rights to test this method, and RISUG reached Phase III clinical trials–much testing concluded that this product was completely safe and effective.  All that is left is to get the product approved and release it to the public.

As a sex health educator, I emphatically support access to new birth control methods, especially additional methods that allow men to have more control over their reproductive choices.  That RISUG will soon be tested in the US is good news indeed, but if you want to do more by signing  the petition, you can help push this method forward.

edit: after reading some comments from Reddit, I think it’s important to address a few things people have been talking about

  • The treatment is effective for at least 10 years.  In trials, none of the subjects have gotten a partner pregnant *yet*. The treatment should be able to last longer, but for now, we know that it works at least this long.
  • The compound coats the sperm, and so it will not affect ejaculation in any way. It only affects the enzymes in the sperm head that bore into the jelly coat of the egg. It is also unlikely that there will be any difference in taste or smell.
  • The only side effect of treatment was swelling of the scrotum that was present up to two weeks after the injection (and even that was only for a fraction of the subjects).  Other than that, no side effects were observed.
  • FYI: THIS METHOD IS NOT HORMONAL. RISUG does not affect testosterone or estrogen production in any way.  The chemical only affects one enzyme on the tip of sperm heads. That is the reason there are few to no side effects.
  • for more information, please visit new male contraception

About sexological

I'm a UCSD graduate in Biology and Psychology. I am working on an academic master's in Psychology at SDSU researching gender differences in perception and cognition. Next year I will be applying to Ph.D. programs so I can hopefully be poor for the rest of my life.
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23 Responses to New contraceptive method to move forward in development!

  1. Michael says:

    What journal did you get published in? Or where can we get info on the clinical trials that you did?

    Thank you!

    • sexological says:

      Thank you for asking. I am actually not the creator of these papers, but if you would like to read the papers, here is a list via
      * Chaudhury, K, AK Bhattacharyya and SK Guha (2004) “Studies on the membrane integrity of human sperm treated with a new injectable male contraceptive.” Human Reproduction 19(8): 1826-30.
      * Guha, SK, G Singh, S Anand, S Ansari, S Kumar and V Koul (1993) “Phase I clinical trial of an injectable contraceptive for the male.” Contraception 48(4): 367-75.
      * Guha, SK (1996) “Contraceptive for use by a male.” United States Patent #5,488,075.
      * Guha, SK, G Singh, S Anasari, S Kumar, A Srivastava and V Koul. (1997) “Phase II clinical trial of a vas deferens injectable contraceptive for the male.” Contraception 56(4): 245-50.
      * Guha, SK (2007) “Biophysical mechanism-mediated time-dependent effect on sperm of human and monkey vas implanted polyelectrolyte contraceptive.” Asian Journal of Andrology 9(2): 221-7.
      * Koul, V, A Srivastava and SK Guha (1998) “Reversibility with sodium bicarbonate of styrene maleic anhydride, an intravasal injectable contraceptive, in male rats.” Contraception 58(4): 227-31.
      * Lohiya, NK, B Manivannan and PK Mishra (1998) “Ultrastructural changes in the spermatozoa of langur monkeys Presbytis entellus entellus after vas occlusion with styrene maleic anhydride.” Contraception 57(2): 125-32.
      * Lohiya, NK, B Manivannan and PK Mishra (2000) “Repeated vas occlusion and non-invasive reversal with styrene maleic anhydride for male contraception in langur monkeys.” International Journal of Andrology 23(1): 36-42.
      * Lohiya, NK, B Manivannan, PK Mishra, S Sriram, SS Bhande and S Panneerdoss (2005) “Preclinical evaluation for noninvasive reversal following long-term vas occlusion with styrene maleic anhydride in langur monkeys.” Contraception 71(3): 214-26.
      * Manivannan, B, PK Mishra and NK Lohiya (1999) “Ultrastructural changes in the vas deferens of langur monkeys Presbytis entellus entellus after vas occlusion with styrene maleic anhydride and after its reversal.” Contraception 59(2): 137-44.
      * Mishra, PK, B Manivannan, N Pathak, S Sriram, SS Bhande and S Panneerdoss (2003) “Status of spermatogenesis and sperm parameters in langur monkeys following long-term vas occlusion with styrene maleic anhydride.” Journal of Andrology 24(4): 501-9.
      * Sharma, U, K Chaudhury, NR Jagannathan and SK Guha (2001) “A proton NMR study of the effect of a new intravasal injectable male contraceptive RISUG on seminal plasma metabolites.” Reproduction 122(3): 431-6.

      for more info, please see the male contraception information project at

  2. Gulrez says:

    Ha ha ! so all the experimentation till now was on poor Indians and the benefits to us while they will not be able to buy this costly patent protected medicines.

    • sexological says:

      That’s not quite true. The Indian company that discovered this technology (as you will see, all the original papers were written by Indian scholars) was not selling until very very recently. A small company finally negotiated and was able to acquire the proper information to re-do the studies in the US and eventually get it approved

  3. Jo says:


    You’re full of shit.

    Not even a grad student, giving medical advice?

    Nice qualifications.

    Fuck off shithead

    • sexological says:

      not a grad student, but I know how to read peer-reviewed papers. And I’m applying. Everyone’s gotta start somewhere. and as far as I can tell, I didn’t give any medical advice, I just explained what the studies showed and shared a new method of contraception in development that i think is really cool.

      • pog says:

        don’t feed the trolls. if people can’t discuss the topic presented in a rational, intelligent manner they don’t deserve the courtesy of anyone’s attention.

    • Jason Dusek says:

      My goodness.

  4. Jo says:

    Also lol@ 90s indian research….

    Got anyone that actually knows something in your field or are you just another quack?

  5. Curtis says:

    Wow, I really want this.

    My girl can get her shot, or I can get my shot for when she complains about it.

  6. Matt says:

    Jo, get off the internet before you hurt yourself.

  7. Jason Dusek says:

    This product can be purchased in India?

    • sexological says:

      no, this product cannot be purchased in India. Pharmaceutical companies there decided the idea was not worth pursuing, so they did not get it approved past phase 3 trials.

  8. tom says:

    So how’d you know it lasts ten years? By direct experiment?

  9. blacklou says:

    would this get injected in my balls? gross dude! i dont want any needles near my shit, dont needle my balls bro

    • sexological says:

      hahaha I would love to see what the world would be like if women reacted this way about contraception.

      “GROSS, DUDE! I don’t want to take hormones that’ll dry me out and make it harder for me to have an orgasm!”

    • Judas says:

      I don’t know about most guys but I’d take a shot to the junk and a swollen scrote for a bit to avoid a bun in the oven for 10 years.

  10. Jeff says:

    Usually when I see something too good to be true, its because it is too good to be true.

    • Daniel Rice says:

      @Jeff, what’s too good to be true? There’s no implication of a miracle here; it’s a simple chemical reaction. Just like everything else.
      If your suspicious because it seems to come out of nowhere, well, just as the author has pointed out before, nobody ever paid attention to contraception from the male angle. So, necessarily, both difficult and simple breakthroughs didn’t occur. Now they are.


  11. Pingback: Male Birth Control Takes a Step Forward in the U.S. — The Good Men Project Magazine

  12. Hi! Nice post; Thanks you))

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